DMSA 25 mg - 90 capsules

DMSA (meso-2,3-dimercaptosuccinic acid) is the active compound in an FDA approved pharmaceutical agent for lead detoxification, and has also been used extensively for the detoxification of other metals such as mercury, antimony and arsenic. DMSA has only about ½ the bioavailability of DMPS from the G.I. tract. Studies performed at DDI indicate that oral DMSA challenges yield significantly less Hg in the urine than IV or oral DMPS. Therefore, many physicians use DMPS rather than DMSA as the initial provocation and monitoring agent for assessment of toxic metal burden. For those who elect to use oral DMSA as the provocation agent, the following protocol is provided:

Protocol for DMSA Provocation Challenge
(1) Stop all non-essential medications and multi-mineral
supplements 24 hours before administration of DMSA. Fish
and shellfish should be avoided for ~1 week prior to the
challenge.
(2) On patient’s initial assessment, a first a.m. urine sample should
be collected with a separate kit and labeled “pre-provocative”.
On an empty urinary bladder and empty stomach, administer
DMSA at 20-30 mg/kg body weight (
d 2 g) as a single oral
bolus dose (J. Nutr Envir Med 1998; 8, 219-231).
(3) All urine should be collected for the following 6 hours. Food
should be withheld for 2 h to ensure efficient absorption of the
DMSA. 0.5-1 L of purified water should be consumed during
collection. Some patients may experience gas, bloating and/or
loose stools with this protocol; such symptoms typically subside
within 6 hours of dosing. Mix the 6-hr. urine specimen well
before taking off the 60 ml aliquot for submission to Doctor’s
Data for analysis