BioFlow

Appetite Suppression & Weight Loss

Tesofensine acts as a potent triple monoamine reuptake inhibitor, reducing food intake and inducing significant weight loss in diet-induced obese rats, in part by normalizing forebrain dopamine levels [1].

Vascular Endothelial Support

In young adults with early vascular dysfunction (e.g., type 1 diabetics), two weeks of taurine supplementation reversed endothelial abnormalities—restoring flow-mediated dilation and arterial stiffness to control levels [2].

Cognitive Enhancement & Synaptic Plasticity

Magnesium L-threonate (MgT) elevates brain Mg²⁺ concentrations, leading to enhanced learning abilities, working memory, and long-term potentiation in rat models, correlated with increased synaptic density in hippocampal subregions [3].

Neuroprotection in Alzheimer’s Models

In APPswe/PS1dE9 transgenic mice, MgT treatment reduced Aβ plaque burden, prevented synapse loss, and rescued memory deficits by stabilizing NMDA-receptor–CREB signaling even in late-stage pathology [4].

References

1. Hansen HH et al. Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat. Pharmacol Biochem Behav. 2013;110:265–271. https://pubmed.ncbi.nlm.nih.gov/23932919/
2. Moloney MA et al. Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics. Diab Vasc Dis Res. 2010;7(4):300–310. https://pubmed.ncbi.nlm.nih.gov/20667936/
3. Slutsky I et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165–177. https://pubmed.ncbi.nlm.nih.gov/20152124/
4. Liu G et al. Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer’s disease mouse model. J Neurosci. 2013;33(10):3815–3827. https://pubmed.ncbi.nlm.nih.gov/23658180/

Note: BioFlow is formulated for investigational research use only and is not approved for diagnostic or therapeutic applications in humans or animals.