Sugar Metabolism Rescue - Mildronate 500 mg capsules - 60 capsules per bottle

Mildronate is the trade name for meldonium (3-(2,2,2-trimethylhydrazinium) propionate). It’s a synthetic compound developed in Latvia in the 1970s and became widely used in Eastern Europe.

Mechanism of Action

• Mildronate inhibits the enzyme γ-butyrobetaine hydroxylase, which normally helps synthesize carnitine.
• Less carnitine → less transport of long-chain fatty acids into mitochondria.
• This shifts cell metabolism away from fatty acid oxidation toward glucose oxidation, which is more oxygen-efficient.
• The result: tissues (especially the heart and brain) use oxygen more efficiently under stress or low-oxygen conditions.

Main Effects

• Improves energy metabolism in ischemic tissues (like heart or brain after reduced blood flow).
• Protects cells from damage during hypoxia (low oxygen).
• Has anti-ischemic, anti-oxidative, and mild vasodilating properties.

Clinical Uses (outside the U.S. & EU)

In Latvia, Russia, and some other countries, it’s prescribed for:

• Angina pectoris (chest pain from reduced blood flow to the heart)
• Heart failure
• Cardiomyopathy
• Cerebral circulation disorders (stroke recovery, chronic brain ischemia)
• Physical and mental fatigue

Sports & Controversy

• Because it increases endurance and recovery, many athletes used it.
• In 2016, the World Anti-Doping Agency (WADA) banned meldonium, adding it to the list of prohibited substances.

Safety & Side Effects

Generally considered well-tolerated, but possible side effects:

• Mild GI upset
• Allergic reactions
• Insomnia or agitation in some cases