Klotho 5 mg vial - When out of stock, this takes 6-8 weeks to get.

Klotho (pronounced KLO-tho, named after the Greek Fate who spins the thread of life) is both a gene and a protein that plays a major role in regulating aging, metabolism, and brain and kidney function.

Here’s a clear overview

1. What Klotho Is

• The Klotho gene (KL) produces the Klotho protein, first discovered in 1997 by Dr. Makoto Kuro-o.
• Mice lacking this gene aged extremely rapidly (wrinkles, arteriosclerosis, osteoporosis, shortened lifespan), while mice with higher Klotho expression lived longer.
• This led to Klotho being called a “longevity gene.”

2. Where It’s Made

• Mainly produced in the kidneys and choroid plexus of the brain.
• Smaller amounts are made in parathyroid glands, pituitary, reproductive organs, and vascular tissue.

There are two forms:

1. Membrane-bound Klotho – acts as a co-receptor for hormones.
2. Soluble Klotho – released into the bloodstream and cerebrospinal fluid; acts more like a hormone itself.

3. What Klotho Does

A. Regulates Mineral and Ion Balance

• Works with FGF23 (fibroblast growth factor 23) to control phosphate and vitamin D metabolism.
• Helps the kidneys excrete excess phosphate — protecting against vascular calcification and kidney damage.

B. Promotes Longevity and Cellular Protection

• Inhibits insulin and IGF-1 signaling (pathways linked to aging and oxidative stress).
• Increases resistance to oxidative damage and inflammation.
• Enhances repair and regeneration in various tissues.

C. Supports Brain Function

• Higher Klotho levels are associated with better cognition and memory, even in people with Alzheimer’s risk genes.
• In mice, extra Klotho improves synaptic function and learning ability.

D. Protects Kidneys and Vessels

• Low Klotho levels are seen in chronic kidney disease (CKD) and are linked to worse outcomes.
• Helps protect blood vessels from calcification and stiffness.

4. Why It Matters

Low Klotho levels are associated with:

• Aging and shortened lifespan
• Kidney disease
• Cardiovascular disease
• Neurodegenerative diseases (Alzheimer’s, Parkinson’s)
• Diabetes and insulin resistance

5. Can Klotho Be Increased?

Research suggests certain factors may increase or preserve Klotho expression:

However, there’s no approved Klotho supplement or therapy in humans yet — though companies are studying recombinant Klotho protein and Klotho gene therapy for kidney failure and cognitive decline.

6. Summary