PNC-28 10 mg - When out of stock, this takes 6-8 weeks to get.
PNC-28 is a lab-made peptide that targets cancer cells by binding to MDM2 on their membranes, punching holes in them, and triggering apoptosis — while largely sparing normal cells. It is experimental but scientifically interesting because it works even in cancers with damaged p53.
What PNC-28 Is
PNC-28 is a 28–amino acid synthetic peptide derived from part of the p53 tumor suppressor protein — specifically, the MDM2-binding domain of p53.
Scientists modified this segment so that the peptide would:
- selectively enter cancer cells
- disrupt their membranes
- trigger cell death (oncolysis)
How PNC-28 Works (Mechanism of Action)
1. Cancer-Selective Membrane Disruption
PNC-28 binds strongly to HDM2/MDM2 proteins, which are overexpressed on the surface of many cancer cells.
This binding allows the peptide to:
- attach to cancer cell membranes
- insert into the membrane
- cause pore formation, leading to cancer cell rupture
This process is called oncotic necrosis.
Importantly, normal cells have much lower MDM2 expression, so the peptide does not accumulate in them and does not damage their membranes.
2. Induction of Apoptosis (Programmed Cell Death)
PNC-28 also activates p53-associated apoptotic pathways inside the tumor cell.
This increases:
- mitochondrial breakdown
- caspase activation
- DNA fragmentation
PNC-28 kills cancer cells two ways:
- Membrane rupture
- Internal apoptotic signaling
3. Works Independent of p53 Mutation
Many cancers mutate p53 to help the tumor survive.
PNC-28 does not rely on the cell having normal p53 because it uses the MDM2-binding domain only, bypassing the normal p53 regulation pathway.
This makes it theoretically useful in cancers with:
- p53 deletion
- p53 mutation
- p53 inactivation
Types of Cancer Studied (preclinical)
PNC-28 has shown anticancer activity in laboratory models of:
- Pancreatic cancer
- Gastric cancer
- Breast cancer
- Melanoma
- Colon cancer
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