Tickborne BBB Direct Detect 3 day – dPCR
The most sensitive test methodology available for direct detection of Bartonella, Babesia, and Borrelia species (spp). (BBB) infections.
People can be exposed to Bartonella, Babesia, and Borrelia through exposure to ticks, fleas, lice, sand flies, and potentially spiders. These vectors can carry multiple pathogens at once, making co-infections common. These stealth pathogens can cause overlapping, persistent symptoms that are often misdiagnosed. Identifying which of these pathogens are present helps providers tailor treatment more effectively—especially since each requires a different therapeutic approach. Without proper testing, co-infections can be missed, leading to incomplete or ineffective care.
Discover the Power of MosaicDX’s Lyme Borrelia Direct Detect profile
Direct testing is particularly valuable in detecting the current presence of pathogens when antibody responses might be absent or unclear. Many patients with detectable spp. DNA never develop detectable antibodies, while others may only show very low titers. The result is that many patients with active pathogens are missed by both conventional PCR and antibody testing. Traditional testing methods may miss active infections due to low pathogen levels or antibody variability.
- Identifies a broad range of Bartonella, Babesia and Borrelia species – utilizing genus level primers
- Identifies cases missed by antibody testing by utilizing direct multiplex DNA detection
- Detects at lower levels by enriching whole blood to increase DNA detection capabilities for Bartonella infections
- Increased sensitivity up to10 times more patients are identified positive when compared to conventional detection methods like qPCR, NGS, and other direct detection methods.
- Confirms DNA in blood for a broad range of Bartonella, Borrelia, and Babesia – Ensures that infection with less common species is not missed.
Tickborne BBB Direct Detect dPCR, confirms current presence of pathogens by directly detecting genus-level DNA for a broad range of Bartonella, Borrelia, and Babesia species (spp) in whole blood. This approach ensures that less common species are not missed.
Digital PCR (dPCR) technology overcomes the limitation of standard PCR testing for low-abundance microbial pathogen DNA by partitioning the sample into approximately 20,000 droplets and then performing a PCR reaction on each droplet. This powerful approach increases the sensitivity of standard PCR detection by up to 10 times.
Whole blood samples are put into BAPGM liquid culture for one week.
Bartonella-specific detection is enhanced through a one-week enrichment in BAPGM liquid culture, Digital PCR (dPCR) is then performed for precise spp identification. Borrelia and Babesia are identified directly from whole blood using the same cutting-edge dPCR technology
Patients presenting with flu-like symptoms, with or without Erythema migrans (EM) rash, and have lived or traveled to an area where Lyme disease is endemic.
Patients with chronic illness not improving, and past/present exposure to ticks, even with past treatment of Lyme, or Post-Treatment Lyme Disease Syndrome (PTLDS) or co-infections.
Patients with chronic illness not improving, and past/present exposure to ticks, fleas, lice, spiders or companion animals.
- Abdominal pain
- Anorexia
- Anxiety and depression
- Arthritis
- Bladder and pelvic pain
- Body aches
- Cardiovascular issues (endocarditis)
- Carditis or heart block
- Changes in bowel habits
- Depression
- Eye and vision problems (such as floaters, light sensitivity, and blurry vision)
- Facial pain and tooth issues
- Fatigue / chronic fatigue / profound fatigue
- Fever
- Fibromyalgia
- Flu-like illness
- Headaches
- Joint pain
- Localized or disseminated EM
- Malaise
- Muscle pain / soreness
- Muscle/limb impairment or paralysis
- Neurological manifestations
- Neurological symptoms such as facial paralysis, blindness
- Psychiatric symptoms (rage)
- Rash “striae”
- Seizures
- Sleeplessness
- Swollen lymph nodes in the head, neck, arms, and along the shins
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