Arterosil

Structure of endothelial glycocalyx and its activation of vascular muscle relaxation via nitric oxide (NO) in response to increased shear force^3,6

The endothelial glycocalyx is a microscopically thin gel-like layer that coats the entire luminal side of the vascular endothelium. It is the key to endothelial health because it prevents cholesterol and other particles from adhering to or penetrating the endothelial wall.

Its functions in vascular and micro-vascular health include:

• Regulates vascular permeability and fluid balance due to the large size and negative charge of its glycosaminoglycans^2,3
• Provides a physical barrier against inadvertent adhesion of platelets and leukocytes to the vascular wall⁴
• Regulates coagulation as many of mediators of coagulation pathway are buried inside the glycocalyx under normal physiological condition⁵
• Functions as a mechano-sensor and transducer of the shear-force inside blood vessels to regulate the synthesis of nitric oxide (NO) in response to the blood flow^3,6

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Practitioner Education

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Glycocalyx Damage and Associated Pathologies

The endothelial glycocalyx is a delicate structure and can be damaged under many conditions. The primary contributors to breakdown of the endothelial glycocalyx are high blood glucose, oxidative stress and inflammation. Pathologies associated with impaired endothelial glycocalyx include:

• Coronary heart disease⁷
• Hyperglycemia⁸
• Diabetes⁹
• Renal diseases¹⁰
• Lacunar stroke¹¹
• Severe trauma¹²

Arterosil contains rhamnan sulfate, a specialized sulfated polysaccharide derived from the green seaweed Monostroma nitidum. Rhamnan sulfate is a glycocalyx regenerating compound (GRC) and has been reported to possess anticoagulant and antithrombotic activity^13.

The rhamnan sulfate found in Arterosil has a similar chemical structure to heparan sulfate found abundantly in human endothelial glycocalyx, and may exert its biological activities by regenerating endothelial glycocalyx.

Arterosil is available exclusively through licensed health care practitioners. Manufactured in the USA, Arterosil currently ships to the 50 United States and Puerto Rico only.

Yes, Arterosil is gluten free. All ingredients can be seen below.

Non-GMO. Does NOT contain gluten, milk, dairy, soy, eggs, fish, crustacean shellfish, tree nuts, peanuts, sesame seeds, celery, mustard, lupine, or mollusks.

Proprietary Blend containing: Green seaweed (Monostroma sp.) extract, grape seed (fruit) extract, green tea (leaf) extract, grape pomace (fruit) extract, tomato (fruit), carrot (root) juice, bilberry (fruit), broccoli (aerial parts), green cabbage (leaf), onion (bulb), grapefruit (fruit), asparagus (stalk), papaya (fruit), pineapple (fruit), strawberry (fruit), apple (fruit), apricot (fruit), cherry (fruit), orange (fruit), blackcurrant (fruit), olive (fruit) extract, cucumber (fruit)

Other Ingredients: Vegetarian capsule (hypromellose), cellulous, maltodextrin, peppermint (natural flavor) silicon dioxide, magnesium stearate, titanium dioxide (natural color), carmine (natural color).

1 capsule 2x per day with or without meals, or as directed by your healthcare professional.

Most impressively, an in vitro study evaluating MonitumRS™, the proprietary extract of rhamnan sulfate from Monostroma nitidum found exclusively in Arterosil HP, has demonstrated full restoration of glucose-compromised endothelial glycocalyx in just 24 hours!†