BerberActiv QR 90 capsules

• Increased Cellular Absorption
  
  
  By encapsulating or complexing berberine with bio-identical lipids (such as phospholipids or specific delivery matrices), the complex shields the berberine molecule, allowing it to pass through the intestinal wall far more efficiently via passive diffusion rather than relying solely on active transport.
• Lower Dosing Requirement with Equal (or Greater) Efficacy
  
  
  Because standard berberine requires high daily doses (typically 1,000 mg to 1,500 mg per day) to achieve therapeutic blood levels, enhanced delivery complexes allow for significantly smaller dosages while achieving equal or superior systemic circulation levels.
• Reduced Gastrointestinal Side Effects
  
  
  High doses of standard berberine often cause localized GI discomfort, including cramping, diarrhea, constipation, or nausea, due to unabsorbed berberine remaining in the intestinal lumen. Lower required doses and higher absorption rates markedly reduce these digestive complaints.
• Enhanced AMPK Activation
  
  
  Once in systemic circulation, berberine acts as a powerful activator of AMPK (AMP-activated protein kinase), often called the body's metabolic "master switch." Higher bioavailability translates to more consistent AMPK activation in liver and skeletal muscle cells.

Primary Health & Metabolic Applications

1. Blood Sugar Regulation & Insulin Sensitivity
   
   
   • Helps downregulate gluconeogenesis (glucose production) in the liver.
   • Upregulates GLUT4 glucose transporters in muscle tissue, facilitating better cellular glucose uptake without over-stimulating insulin production.
2. Lipid & Cholesterol Management
   
   
   • Inhibits PCSK9, a protein that degrades LDL receptors, allowing the liver to clear more LDL ("bad") cholesterol from the bloodstream.
   • Supports healthy triglyceride levels and HDL balance.
3. Weight & Metabolic Support
   
   
   • Promotes mitochondrial efficiency and fat oxidation.
   • May help regulate adipogenesis (the formation of new fat cells) via metabolic signaling.
4. Cardiovascular & Endothelial Function
   
   
   • Supports nitric oxide production in blood vessels, promoting healthy vascular dilation and circulation.

Serving Size: 1 Capsule

Servings per Container: 90

Ingredient

Other Ingredients: CyLoc™ gamma dextrin fiber matrix, hypromellose (derived from cellulose) capsule, capsule, calcium laurate and plant amylase.

Take 1-2 capsules two times daily or as recommended by your health-care practitioner.

Serving Size:One Capsule

Amount Per Serving: Berberine complex ... 350 mg

Other Ingredients:
CyLoc™ gamma dextrin fiber matric, hypromellose (derived from cellulose) capsule, capsule, calcium laurate and plant amylase.

More than 2,000 studies demonstrate the many benefits of berberine, a compound extracted from the roots of Berberis aristate. What does all this research show? Supporting glucose metabolism tops the list.*

A meta-analysis of 28 clinical trials that evaluated berberine's efficacy concluded that berberine can significantly improve the biomarkers associated with blood glucose metabolism.* (Berberine benefits glucose metabolism by stimulating glycolysis via increasing the activity of glucokinase¹. But Berberine’s benefits don't end there!

Berberine also supports gastrointestinal health, cardiovascular function, lipid metabolism, healthy weight management, and liver function¹. It’s all made possible because of berberine's powerful ability to stimulate AMP-activated protein kinase (AMPK), the body’s primary energy regulatory switch.* AMPK is involved in moderating the critical biochemical pathways found in the cells of various organs, such as the brain, kidney, heart, and liver.*

BerberActiv®  is available in both quick release and sustained-released formulations and is powered by Tesseract's revolutionary CyLoc® and DexKey® delivery system, which ensures its optimal absorption – one molecule at a time.

Solubility-enhanced berberine (from Berberis aristata (root) extract) in CyLoc®, dextrin fiber matrix molecular traps. CyLoc® complexes compounded with DexKey® release agents (patent pending, Al Czap, Czap R&D, licensed by Tesseract Medical Research