SS-31 25 mg vials - When out of stock, this takes 6-8 weeks to get.

The SS-31 peptide (also known as elamipretide) is a small, mitochondria-targeted peptide with significant biological and therapeutic value due to its ability to protect and restore mitochondrial function.

Here’s a concise overview of its value and key properties:

Basic Information

• Name: SS-31 (Elamipretide)
• Sequence: D-Arg-Dmt-Lys-Phe-NH₂
  (Dmt = 2’,6’-dimethyltyrosine)
• Molecular Weight: ~639.8 Da
• Type: Cell-permeable, mitochondria-targeting tetrapeptide

Mechanism of Action

SS-31 binds specifically to cardiolipin, a unique phospholipid in the inner mitochondrial membrane.
By doing so, it:

• Stabilizes mitochondrial membranes
• Reduces reactive oxygen species (ROS) production
• Improves ATP generation
• Prevents cytochrome c leakage (which triggers apoptosis)

Essentially, it restores mitochondrial integrity and energy output while reducing oxidative stress.

Key Benefits (Observed in Studies)

1. Improved mitochondrial efficiency and bioenergetics.
2. Protection against ischemia-reperfusion injury (heart, kidney, brain).
3. Anti-aging and neuroprotective effects (shown in models of Alzheimer’s, Parkinson’s, and retinal degeneration).
4. Enhanced muscle strength and endurance in aging models.
5. Reduced inflammation and oxidative damage.

Research & Clinical Applications

• Cardiovascular disease (heart failure, ischemia)
• Mitochondrial myopathies (e.g., Barth syndrome)
• Neurodegenerative diseases
• Retinal disorders (dry AMD – age-related macular degeneration)
• Kidney protection during drug toxicity or ischemia

Several human clinical trials have shown safety and mitochondrial improvements, though large-scale efficacy trials are still ongoing.